Please review the information below carefully prior to assembling your Nuclear Receptor Signaling manuscript. 

SUBMISSION

Manuscripts may be submitted via the Nuclear Receptor Signaling ScholarOne site.

ENDNOTE™ STYLE

The Endnote™ Style for Nuclear Receptor Signaling may be downloaded here.

AIMS AND SCOPE

Nuclear Receptor Signaling publishes primary research articles, reviews, methods and dataset reports in all mechanistic, functional and pathological aspects of nuclear receptor signaling. The Editors-in-Chief welcome submissions representing the broad range of disciplines in this field, including cell biology, biochemistry, physiology, chemistry, pharmacology and informatics, as well as clinical and translational studies. The scope of this journal is to act as a unique, pan-disciplinary home for innovative and insightful research in nuclear receptor signaling.

MEDLINE AND PubMed Central

Nuclear Receptor Signaling is indexed in MEDLINE and full text articles are available on PubMed Central. Browse a list of previously published Nuclear Receptor Signaling articles on PubMed and PubMed Central.

OPEN ACCESS

Nuclear Receptor Signaling is an Open Access journal, as defined by the Bethesda Statement on Open Access Publishing. Accordingly, authors retain copyright of their published articles, under a Creative Commons Attribution-Non Commercial License. The conditions of publication in Nuclear Receptor Signaling permit unrestricted noncommercial use, distribution and reproduction in any medium, provided the original Nuclear Receptor Signaling article is properly cited. By submitting a manuscript for review, the corresponding author implies acceptance of these conditions on behalf of all authors.

ARTICLE PROCESSING CHARGES

There are currently no article processing charges. Nuclear Receptor Signaling is published as a community resource by staff in the Nuclear Receptor Signaling Atlas (NURSA) Informatics Hub supported by an award from the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) U24 DK097748. 

EDITORIAL PROCESS AND POLICIES

Manuscripts are submitted online and distributed for peer review by the Editors-In-Chief. Authors may suggest reviewers but have no input into their selection, nor are the identities of the reviewers disclosed to the authors at any time. Authors can typically expect a decision on their manuscript within three weeks of reviewer assignment. A decision will be made by the Editors In Chief based upon the returned reviews. In situations where a conflict arises, a member of the editorial board will be enlisted to render their opinion on the manuscript.

Manuscripts with multiple authors are reviewed on the understanding that all listed authors agree to the submission of the manuscript and that the final version has been seen and approved by all authors. Listed authors should have made significant contributions to designing the experiments, generating data, or carrying out analysis and interpretation. Individuals involved in drafting the manuscript or carrying out critical revisions should also be listed as authors. Manuscripts containing evidence of plagiarism, unacknowledged previously published data or selective image manipulation will be withdrawn from consideration or, if already published, retracted and replaced with a notice indicating this retraction. Manuscripts should be submitted only after permission to reproduce figures, tables or other content previously published elsewhere has been obtained from the copyright holder. All submitted manuscripts must contain a statement on the first page outlining any financial conflict-of-interest. 

In all matters the decision of the Editors-In-Chief is final and binding, and during the submission process authors will be required to indcate that they are aware of the policies of the journal and agree to be bound by them.

Accepted articles are released immediately on the NRS website as unformatted First Look PDFs, and subsequently as fully formatted articles in HTML and PDF form. Note that under our arrangement with NCBI, articles are searchable on PubMed only after the full text has been submitted to NCBI.

PUBLICATION CRITERIA

Manuscripts should communicate their findings in such a way that adds to our understanding of how NRs, their ligands and coregulators, co-ordinate spatiotemporal regulation of gene expression. Uniquely, Nuclear Receptor Signaling articles will, where appropriate, be cross-referenced with NURSA Molecule Pages and data analysis tools, providing readers with background and context for the papers. In order to facilitate this, authors of accepted manuscripts must provide a list of the key NRs, ligands and coregulators relevant to their manuscript. Manuscripts describing a new dataset will be required to contain an accession number in an appropriate public data repository prior to acceptance.

Nuclear Receptor Signaling places no restrictions on the length of a manuscript, nor the number of figures and tables, in any article category. Each category has distinct review criteria –  for guidance on the overall suitability of a manuscript for the journal and the most appropriate article category, please send a presubmission enquiry to the editorial office.

ARTICLE CATEGORIES

Research Research articles are reports of original, hypothesis-driven research of functional, mechanistic or clinical significance in nuclear receptor signaling. Manuscripts accepted in this category are judged to make a novel and important contribution to understanding the role of nuclear receptors, their ligands and coregulators in regulating biological processes. Manuscripts must not be under consideration at another journal. All previously unpublished 'omics-scale datasets relevant to the manuscript must be deposited in a public repository prior to acceptance. The Editors-In-Chief may at their discretion invite authors to resubmit a Research manuscript as a Perspective manuscript (see below).

Reviews Reviews of the nuclear receptor signaling literature are welcome which focus either on one or more aspects of a specific molecule, or on specific structural, functional or biological commonalities between larger numbers of molecules; or reviews of the application of a technique in the field. Reviews of meetings in the nuclear receptor field are also welcome. Reviews shall be unbiased and impartial, and shall incorporate a variety of conflicting data or models in a specific area. Inclusion of a model figure summarizing current knowledge in the area is strongly encouraged. The inclusion of previously-unpublished primary research data is not appropriate in Review articles.

Perspectives Perspectives are intended as a forum in which authors can make a case for a particular experimental models which, while not fully validated experimentally, nevertheless represent an interesting topic for discussion in the field. Perspectives should be worded so as to emphasize that such models are preliminary in nature and require additional supporting in vitro and/or in vivo evidence in order to be fully substantiated. The Editors-In-Chief may at their discretion invite authors to resubmit a Research manuscript as a Perspective manuscript.

Methods Methods articles are original descriptions of the application of a novel or existing method with specific relevance to the field of nuclear receptor signaling. Submissions which address the need for standardization of experimental procedures or describe strategies for developing high-throughput platforms for such techniques are particularly welcome. Please note that descriptions of hypothesis-driven research which in the editor’s opinion emphasize the significance of experimental findings over the technique are not appropriate for submission to NRS. 

Datasets The field of nuclear receptor signaling generates a large number of global transcriptomic, proteomic, gene-wide location analysis, epigenomic and metabolomic datasets. When properly annotated and validated, such discovery-driven datasets are valuable resources for hypothesis generation or refinement, or data validation. The suitability of manuscripts describing such datasets for publication in Nuclear Receptor Signaling will depend upon their technical accuracy and reliability, their scientific merit, as well as their potential for advancing knowledge of the physiological roles of nuclear receptor signaling. Manuscripts in this category will be shorter than a full research manuscript and should avoid over-interpretation of the dataset. For information regarding the suitability of a particular study for submission as a Dataset, please contact the editorial office

MANUSCRIPT SPECIFICATIONS

The acceptable file types for the main text document for a new submission are Adobe PDF (.pdf) or Microsoft Word (.doc). For revised manuscripts, only Microsoft Word  (.doc) files are acceptable. The main text document should be named with the first author’s surname and the appropriate file extension, e.g. surname.pdf, surname.doc.

Nuclear Receptor Signaling accepts manuscripts written in English. Manuscripts submitted to Nuclear Receptor Signaling which do not meet reasonable standards of spelling or grammar will not be reviewed. All editorial decisions should be considered final.

Manuscript documents must adhere to the following specifications:

- Formatted for standard US letter size paper (8.5 inches x 11 inches). Margins should be 1.5 inches in width on all sides. 
- Double-spaced and unjustified (flush left margin, ragged right margin) throughout, including figure legends, table legends and references.
- Typed in 11 point text or higher
- Pages should be numbered in the lower right hand corner, with the title page serving as page 1
- Greek symbols; use the appropriate Greek symbol (α, β, γ, etc) in your manuscript document, not spelled out.
- Chemical & mathematical equations and structural formulae should be grouped in a single graphic and referred to from the text as with any other figure (e.g. Figure 4, Equation 3).
- SI units should be used throughout the manuscript

MANUSCRIPT LAYOUT

The main text document MUST be laid out in the order specified below. Start a new page for the Abstract, Introduction, Materials and Methods, Results, Discussion and References. Do not number sections and subsections.

Title The title should not contain non-standard acronyms or abbreviations. Abbreviation of nuclear receptors, their ligands and coregulators is permitted. The journal may require modification of a title to conform to house style prior to acceptance of a manuscript.

Authors and affiliations Authors should be matched with unique institutions in parentheses after the appropriate organizations or departments or divisions within an organization, according to the following example:

Ping Gong, Zeynep Madak-Erdogan, Jilong Li, Jianlin Cheng, C Michael Greenlief, William G Helferich, John A Katzenellenbogen and Benita S Katzenellenbogen
Botanical Research Center (PG, ZME, WGH, JAK, BSK) and Departments of Molecular and Integrative Physiology (PG, ZME, BSK), Food Science and Human Nutrition (WGH) and Chemistry (JAK), University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; and Botanical Research Center, University of Missouri, Columbia, MO 65211, USA (JL, JC, CMG)

Corresponding Author The corresponding author’s full mailing address (with country), phone number, fax number and e-mail address must be provided separately, with its own heading, beneath the institutes.

Author contributions Indicate the contribution of all authors in at least one of the following categories (1) conception and design of the study; (2) generation, collection, assembly, analysis and/or interpretation of data; (3) drafting or revision of the manuscript; and (4) approval by all the authors of the final version of the manuscript. Please note the following example:

PG, ZME, CMG, WGH, JAK and BSK conceived and designed the project; PG, ZME, JL, JC, and CMG performed the experiments; all authors discussed and analyzed the data; PG, ZME, CMG, JAK and BSK wrote the manuscript; all authors read and approved the manuscript. 

Running head Include a shortened version of the title of the manuscript

Authorship statement The following statement must be included on the first page: "This manuscript is not under consideration by another journal and all authors agree to the submission of the manuscript, have approved the final submitted copy, and are aware of and agree to be bound by the editorial policies of Nuclear Receptor Signaling."

Abstract The abstract must be on its own separate page and should be a single continuous narrative with no subheadings. References should not be cited in the abstract.

Key words Include 4-5 keywords that directly relate to the manuscript

Abbreviations All non-standard abbreviations should be defined at their first mention in both the abstract and the main text. In addition, they should be listed, along with their definitions, in alphabetical order after the keywords in the following format:

BCL6, B-cell lymphoma 6 protein; BAT, Brown adipose tissue; ChIP, Chromatin Immunoprecipitation; CHD, Coronary heart disease; DBD, DNA-binding domain; FAO, Fatty Acid Oxidation; FA, Fatty Acid...etc

Dataset accession numbers Full review of  a manuscript requires reviewer access to any associated complete datasets. Nuclear Receptor Signaling therefore requires that all 'omics-scale datasets be submitted to an appropriate public repository prior to submission. Manuscripts referring to an unarchived dataset and that do not contain a corresponding accession number will not be reviewed. A list of NIH-designated repositories can be found on the NIH Genomic Data Sharing website.

Introduction The introduction should emphasize the broad nature of the issue which the article addresses, with reference to key publications. 

Materials and Methods All relevant reagents and instruments and methods used in the work should be included in this section, including the name of the manufacturer, country (with city if in the United States) and, where possible, the product or part number. 

Results Combine all results and observations under declarative, informative subheadings 

Discussion This section should contain discussion and intepretations of the data, with subheadings where appropriate.

Acknowledgements Please cite any assistance from individuals not named in the author list, along with funding sources, including the sponsoring organization and the full grant number.

Competing Interests Refer to any financial conflict-of-interest for any author, or indicate explicitly that none exists.

References The Endnote Reference Style for Nuclear Receptor Signaling can be downloaded here

References may include journal articles (published or in press) and published book chapters or sections. Personal communications and unpublished observations should not be cited in the reference list, but should be mentioned in the main text where appropriate. Conference proceedings and abstracts are not permitted as citations. Citations of relevant websites and databases are encouraged. URLs should be cited using the name of the website home page, the year accessed and the digital object identifier (DOI), if available. URLs must not be provided in the body of the manuscript text.

Authors submitting manuscripts with manually typed references should note the following styles carefully to ensure they conform with the Nuclear Receptor Signaling style. Accepted manuscripts containing manually entered references will be delayed in publication, due to the extra work required in the editorial office to format these references.

All references should be cited in the text in parentheses per Nuclear Receptor Signaling style with the corresponding year, according to this example paragraph:

This is an example of a single author citation (Smith, 1999), and this is an example of a two-author citation (Smith and Jones, 2000).  This is an example of three or more authors (Smith et al., 2001). In the case of multiple references at the end of a sentence, group in parentheses separated by a semi colon (Smith et al., 2003; Jones et al., 2004). In the case of two references with the same first author and year, use a and b to distinguish them (Smith et al., 2003a; Smith et al., 2003b). Finally. this is an example of a personal communication (J. Smith, personal communication), and this is an example of a website citation (Animal Models of Diabetes Complications Consortium, 2004).
For manually entered references, type the reference list as follows

1. Individual article in a journal

Baniahmad, A., Leng, X., Burris, T. P., Tsai, S. Y., Tsai, M. J. and O'Malley, B. W. (1995). The tau 4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Mol Cell Biol 15, 76-86. 

2. Individual article in a journal supplement

Carstensen, J. F., Tesdorpf, J. G., Kaufmann, M., Markus, M. M., Husen, B., Leenders, F., Jakob, F., de Launoit, Y. and Adamski, J. (1996). Characterization of 17 beta-hydroxysteroid dehydrogenase IV. J Endocrinol 150 Suppl, S3-12. 

3. Journal article in press

Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H. and Reichardt, L. F. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci, in press.

Please note if you are using Endnote or another reference software, ensure that for articles in press, the “Year” field must be left blank and the words “In Press” must be typed in the “Volume” field.

4. Book chapter 

Baum (1999). Neuroendocrine control of psychosexual development. In Fundamental Neuroscience, M. J. Zigmond, and A. Smith, eds. (New York, Academic Press), pp. 1229-1244.

5. Entire book

Lewin, B. (1997). Genes, 6th edn (New York, Oxford University Press).

6. Web link / URL

Authors must ensure that the full website name is correctly included in the citation, and that the URL and digital object identifier (DOI) is accurately reproduced in the reference listing e.g. Animal Models of Diabetes Complications Consortium (2004) http://www.amdcc .org/index.asp

Figure Titles and Legends Figure titles should be brief, no more than 20 words. Legends should be a detailed summary of the contents of the table, but no more than 300 words. 

Tables Tables must be inserted as Microsoft Word tables at the end of the paragraph in which they are first called out. Place the table number and title above the table and any footnotes below. Please do not (i) embed Word documents containing tables in the main text file or (ii) use text boxes to insert table titles or footnotes.

Tables should be single-spaced and numbered in Arabic numerals with a short title. Where necessary, legends should be included only as footnotes to the table. Please ensure that all tables are referred to in the text at least once. 

All tables must be sized to fit on a single US Letter (8 x 11) page at Calibri 6 point text. Tabular content that will not fit on a single US Letter page must be broken into separate tables or submitted as Supplementary Material. Citations in tables must be listed in the main reference list. 

Supplementary Material Large files containing any other material relevant to the publication, such as worksheets routinely used in the authors’ laboratory, spreadsheets, movies or animations may be submitted as supplementary files in a single zipped folder. Refer to each piece of supplementary data by name in the text (e.g. See Supplementary Figure 1, Supplementary Table 2). Include in the zipped folder a document containing the title and legend for each supplementary file.

FIGURES

Figures include models, schematics, flow diagrams, charts, photomicrographs, etc. must be submitted separately from the main text document as .TIFF or .EPS files (300 dpi minimum). We strongly advise against creating figures in Powerpoint, as this will result in resolution problems when they are converted to .TIFF or .EPS, the required formats for accepted articles. Rather, figures should be created in a vector graphics program (Adobe Illustrator, Adobe Photoshop, Corel DRAW) and saved as 300 dpi (minimum) .TIFFs or .EPS files. Authors will be required to resubmit figures that do not meet the above standards prior to final acceptance of a manuscript.

Reviews and perspectives must contain at least one figure or table. As a guide, there should be one figure or table per 2,500 manuscript words.

Bar charts should contain scale bars and indications of experimental error where appropriate. All figures must be numbered and referred to at least once in the text. They must have an associated title and legend in the text document – these should not appear on the Figure itself. Figures should be cropped to minimize the amount of white space surrounding the illustration. Multipart figures, such as a montage of photomicrographs, cartoons or bar charts, should be grouped in a single composite illustration, with each component clearly labeled in a lower case letter (a, b, c), etc. 

Chemical structures Individual chemical structures and/or structural series must not be provided in the main text body, but grouped together in a figure and cited as appropriate.

Genes Approved gene symbols must be italicized and case-sensitive: NCOA3 for human, Ncoa3 for mouse and rat, ncoa3 for fly