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NRS 12, e001 | Figure 2

Gong P, Madak-Erdogan Z, Li J, Cheng J, Greenlief CM, Helferich WG, Katzenellenbogen JA and Katzenellenbogen BS (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12, e001. doi:10.1621/nrs.12001

Figure 2

Figure 2. Hierarchical clustering of the genes regulated by BEs and E2 in the three ER cell backgrounds Hierarchical clustering is shown for all four compounds and cell backgrounds (Panel A), and individually for ERα only (Panel B), ERα + ERβ (Panel C), and ERβ only (Panel D) cells. Several identified clusters showing different patterns of gene regulation by the ligands in the different cell backgrounds are denoted by letters a-f.