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NRS 12, e001 | Figure 3

Gong P, Madak-Erdogan Z, Li J, Cheng J, Greenlief CM, Helferich WG, Katzenellenbogen JA and Katzenellenbogen BS (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12, e001. doi:10.1621/nrs.12001


Figure 3. Principal component analysis (PCA) of RNA-seq Data RNA-seq reads of each sample were mapped to known and new genes. Differentially regulated genes were determined by comparison of the gene expression level with E2 or BE treatment vs. Veh in the same ER background. Differentially regulated genes were considered to be those with a ≥2-fold difference in expression level and an FDR of 0.01. The expression values of differentially regulated genes in Veh and treatment groups in all 3 cell types were subjected to PCA.