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NRS 12, e001 | Figure 4

Gong P, Madak-Erdogan Z, Li J, Cheng J, Greenlief CM, Helferich WG, Katzenellenbogen JA and Katzenellenbogen BS (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12, e001. doi:10.1621/nrs.12001


Figure 4. Comparison of the genes regulated by the three BEs and by E2 in the three ER cell backgrounds (ERα only, ERα + ERβ, ERβ only) Cells were treated with genistein, S-equol or liquiritigenin (1 μM) or E2 (10 nM) for 24 h prior to harvest of RNA and further processing. Venn diagrams show overlap of BEs and E2 for up- and down-regulated genes in the three cell backgrounds.