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NRS 12, e001 | Figure 7

Gong P, Madak-Erdogan Z, Li J, Cheng J, Greenlief CM, Helferich WG, Katzenellenbogen JA and Katzenellenbogen BS (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12, e001. doi:10.1621/nrs.12001


Figure 7. Examples of genes whose expression was preferentially stimulated by E2 or BEs in cells containing ERα+ERβ compared with cells containing ERα only or ERβ only. Cells were treated with control vehicle (0.1% ethanol), 10 nM E2, or 1 μM genistein, S-equol, or liquiritigenin for 24 h prior to harvest and real-time PCR analysis. mRNA fold change is shown for specific genes in the three cell types. Real-time PCR data shown are mean ± SD for triplicate analyses.