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NRS 12, e001 | Figure 8

Gong P, Madak-Erdogan Z, Li J, Cheng J, Greenlief CM, Helferich WG, Katzenellenbogen JA and Katzenellenbogen BS (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12, e001. doi:10.1621/nrs.12001

Figure 8

Figure 8. Examples of genes whose expression was preferentially stimulated by E2 or by BEs in cells containing only one ER (ERα or ERβ). Cells were treated with control vehicle (0.1% ethanol), 10 nM E2, or 1 μM genistein, S-equol, or liquiritigenin for 24 h prior to harvest and real-time PCR analysis. mRNA fold change is shown for the specific genes in the three cell types. (Panel A) Example of a gene stimulated more by all compounds in ERα only cells. (Panels B-I) Examples of genes stimulated more by E2 or BEs in ERβ only cells. Values are from real-time PCR determinations and are mean ± SD for triplicate analyses.