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Figure 9. Examples of genes down-regulated by E2 or BEs compared between cells containing the three complements of ER Cells were treated with control vehicle (0.1% ethanol), 10 nM E2, or 1 μM genistein, S-equol, or liquiritigenin for 24 h prior to harvest and real-time PCR analysis. mRNA fold change is shown for the specific genes in the three cell types. A-C, immune response genes, D-F, tumor suppressor genes, G-I, genes associated with invasion. Values are mean ± SD for triplicate analyses.