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NRS 12, e002 | Figure 7

Wu DY, Ou CY, Chodankar R, Siegmund KD and Stallcup MR (2014) Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators Nucl Recept Signal 12, e003. doi:10.1621/nrs.12002


Figure 7. Regulation of gene expression occurs at multiple levels. In our model system, nuclear receptors bind to enhancers after hormone treatment and recruits coregulators. Different coregulators are recruited to (and/or required for) each enhancer and each enhancer regulates one or a few target genes. Coregulators can serve as an intermediate regulatory step for hormone regulation through differential recruitment to and requirement for enhancers as well as having both coactivating and corepressive effects.