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NRS 12, e003 | Table 1

Wu DY, Ou CY, Chodankar R, Siegmund KD and Stallcup MR (2014) Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators Nucl Recept Signal 12, e003. doi:10.1621/nrs.12002

 

Table 1. Hits from the compound libraries. Compounds identified from the screening cascade as binders to ERβ ranked by their half maximal inhibitory concentration (IC50) for ERβ determined from a fluorescence polarization assay and compared with their IC50 obtained for ERα. A melting temperature for each compound with ERβ LBD obtained from DSF is also included as well as the EC50/IC50 for ERβ determined from the cell-based transactivation assay.