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NRS 12, e004 | Figure 3

Liu X and Giguère  (2014) Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transition. Nucl Recept Signal 12, e002. doi:10.1621/nrs.12003

 

Figure 3. Inhibition of epithelial-mesenchymal transition in Wnt1-induced Rarb-null tumors. (a) Differential gene expression analysis of the microdissected epithelial compartment of MMTV-Wnt1 and MMTV-Wnt1/Rarb-/- tumors. Data are presented as relative fold change (log2) vs. wild-type stroma. (b) Western blot analysis of markers of epithelium undergoing EMT in lysates derived from MMTV-Wnt1 and MMTV-Wnt1/Rarb-/- tumors. (c) Expression of E-cadherin (red) and Ki67 (green) as monitored by immunofluorescence in MMTV-Wnt1 and MMTV-Wnt1/Rarb-/- tumors. (d) Nuclear localization of β-catenin (green) as monitored by immunofluorescence.