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NRS 12, e004 | Figure 5

Liu X and Giguère  (2014) Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transition. Nucl Recept Signal 12, e002. doi:10.1621/nrs.12003

 

Figure 5. Rarb is crucial for the interaction between tumor cells and stromal cells. Schematic representation of perturbed signaling pathways in Wnt1-induced tumors and their microenvironments in wild-type and Rarb-/- mice. Loss of Rarb leads to remodeling of the stroma (bars), reduced Wnt-1 signaling in CAFs, decreased IGF-1 levels and inhibition of EMT in the tumor as assessed by lower expression of Snail, decreased and increased AKT and GSK-β phosphorylation, respectively.