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NRS 12, e005 | Figure 2

Cato L, Neeb A, Brown M and Cato AC (2014) Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L. Nucl Recept Signal 12, e005. doi:10.1621/nrs.12005


Figure 2. The structure of TPR-containing and TPR-lacking cochaperones. Top: Domain structure of cochaperones containing tetratricopeptide repeats (TPR) motifs. All TPR motifs are shown in yellow. Other important protein domains are indicated. Bottom: The domain structures of three cochaperones (p23, AHA1 and BAG-1) lacking the classical TPR motifs, with their Hsp90/Hsp70-binding domains highlighted in blue. All domain information (including residue numbers) were obtained from the RefSeq database (NCBI) [102]. STI1: Stress inducible protein 1 (Heat shock protein binding motif); NLS: Nuclear localization signal; PPlase: Peptidyl-prolyl cis-trans isomerase. ARM: Armadillo; CS: CHORD-containing protein SGT1; Aha1: Activator of Hsp90 ATPase; SRPBCC: START/RHOs_alpha_C/PITP/Bet v 1/CoxG/CalC: UBQ: Ubiquitin-like domain; BAG: Bcl-2-associated athanogene (Heat shock protein binding motif). Single alphabet letters (with or without separation by a slash) correspond to particular amino acids (or amino acid sequences) that are over-represented in a certain region.