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NRS 12, e005 | Figure 3

Cato L, Neeb A, Brown M and Cato AC (2014) Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L. Nucl Recept Signal 12, e005. doi:10.1621/nrs.12005


Figure 3: The Bag-1 protein family members and their structural domains. A. Top: Intron-exon structure of the human Bag-1 gene and corresponding transcript. The start codons for the different Bag-1 transcripts are indicated by arrows. Note, Bag-1L, the longest family member, is the only one with a CUG start codon. Bottom: The domain structures of the four human Bag-1 isoforms (left) and the two isoforms of Schizosaccharomyces pombe (right), with their Hsp70/Hsc70-binding domains (BAG) highlighted in blue. The TR/QSEEX repeat region is shown as vertical lines and other functional domains are indicated. The domain information (including residue numbers) for the human Bag-1 isoforms were obtained from the RefSeq database (NCBI) [102], while the domain information for the yeast homologues were taken from Kriegenburg et al. 2014 [103]. NLS: Nuclear localization signal; UBQ: Ubiquitin-like domain; TM: Transmembrane domain. B, C. Phylogenetic tree (B) and sequence alignment (C) of the first 80 N-terminal amino acids of the human Bag-1L protein compared with Bag-1 isoforms in other organisms. Both graphs were generated using the MultAlin website [104].