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NRS 13, e002 | Figure 2

Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S, Auerbach S, Geter D, Aleksunes L, Thomas R, Applegate D, Klaassen D and Corton J (2015). Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. Nucl Recept Signal 13, e002. doi:10.1621/nrs.13002




Figure 2. Characterization of the CAR biomarker signature. A. Expression behavior of genes in the signature. The heat map shows the expression of the 128 probe sets after exposure to CITCO, phenobarbital (PB), and TCPOBOP in wild-type and CAR-null mice compared to the final signature. B. Expression behavior of the CAR signature genes in the Comparative Toxicogenomics Database (CTD). The signature shows the fold-change of the genes. To the right of the signature, yellow and blue represents the number of publications which showed increased or decreased expression of the gene, with intensity representing the number of individual publications which showed the effect. Green represents genes where there is conflicting information regarding the expression of the gene by the chemical exposure, which could be due in part to lack of annotation of tissue of origin. PB, phenobarbital; Cypro, cyproconazole; Epoxi, epoxiconazole; Flu, fluconazole; Propi, propiconazole; Tri, triadimefon. C. Top canonical pathways enriched for the genes in the CAR biomarker signature. Genes were examined by Ingenuity Pathways Analysis. D. Top transcription factors predicted to regulate the genes in the CAR biomarker signature, as determined by Ingenuity Pathways Analysis.