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NRS 13, e002 | Figure 5

Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S, Auerbach S, Geter D, Aleksunes L, Thomas R, Applegate D, Klaassen D and Corton J (2015). Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. Nucl Recept Signal 13, e002. doi:10.1621/nrs.13002




Figure 5. Activation of CAR by AhR activators. A. Activation of CAR by TCDD. Activation of CAR by TCDD in two studies in which transcriptional effects were examined. (Left) Wild-type and AhR-null mice were exposed to 1 mg/kg of TCDD for 19 hrs (from study GSE10082). (Right) Three strains of mice were exposed to two dose levels of TCDD (from E-MEXP-1231). B. Activation of CAR by benzo[a]pyrene (B[a]P) in three studies in which transcriptional effects were examined. (Left) The Hepa1c1c7 and AhR-null Hepa1c1c7 cell lines were exposed to 5 μM B[a]P for 8 hrs (from study GSE11796). (Middle) Primary hepatocytes from wild-type or Xpa1/p53-null mice were exposed to four dose levels of B[a]P for 24 hrs (from study E-TABM-1139). (Right) Hepatocytes from wild-type mice were dosed with 30 μM of B[a]P (from E-MEXP-2209).