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NRS 13, e002 | Figure 6

Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S, Auerbach S, Geter D, Aleksunes L, Thomas R, Applegate D, Klaassen D and Corton J (2015). Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. Nucl Recept Signal 13, e002. doi:10.1621/nrs.13002




Figure 6. Effect of PXR activators on CAR activation. (Left) Activation of CAR by PXR activators is diminished or abolished in PXR-null mice (from this study and GSE23780). Wild-type or PXR-null mice were treated each day with pregnenolone-16-α-carbonitrile (PCN, 400 mg/kg) or compound 13 (C13, 150 mg/kg) for 4 days. (Right) Activation of CAR marker genes by PCN in wild-type and PXR-null mice. *Significant from corresponding control at p-value < 0.05; **Significant from corresponding control at p-value < 0.01; #significant between wild-type and nullizygous comparisons at p-value < 0.05; ##significant between wild-type and nullizygous comparisons at p-value < 0.01.