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NRS 13, e002 | Figure 8

Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S, Auerbach S, Geter D, Aleksunes L, Thomas R, Applegate D, Klaassen D and Corton J (2015). Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. Nucl Recept Signal 13, e002. doi:10.1621/nrs.13002




Figure 8. Conazole fungicides activate CARA. Effects of exposure to 5 conazoles on CAR activation. Biosets were derived from Ward et al. (2006) (for Myclo, Propi, and Triad) or Hester et al. (2012) (for Cypro and Epoxi) studies. Abbreviations: Cypro, cyproconazole; Epoxi, epoxiconazole; Myclo, myclobutanil; Propi, propiconazole; Triad, triadimefon. B. Liver to body weight ratios of wild-type and CAR-null mice given propiconazole (210 mg/kg) or triadimefon (165 mg/kg) for 7 days. **Significant from corresponding control at p-value < 0.01. C. Hepatocyte proliferation in wild-type and CAR-null mice exposed to propiconazole for 7 days. Hepatocyte proliferation was evaluated as detailed in the Methods. *Significant from corresponding control at p-value < 0.05. D. Expression of marker genes for CAR and PXR in the livers of wild-type and CAR-null mice given propiconazole or triadimefon for 7 days. **significant from corresponding control at p-value < 0.01; ##significant between wild-type and nullizygous comparisons at p-value < 0.01.