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NRS 13, e003 | Figure 6

Morrill GA, Kostellow, AB and Gupta RK (2015) Transmembrane helices in "classical" nuclear reproductive steroid receptors: a perspective. Nucl Recept Sig 13, e003. doi:10.1621/nrs.13003




Figure 6. PoreWalker analysis. Androgen receptor ligand binding domain complex with dihydrotestosterone (left column, PDB ID: 1i37) and the estrogen receptor ligand binding domain (right column, PDB ID: 1A52). The upper plot illustrates the pore diameter profile, whereas the lower image illustrates the features of the cavity. The protein structure is colored in green and red spheres represent pore centers at given pore heights and their diameters are proportional to the pore diameter calculated at that point. The lower visualization of a pore section shows the position of the biggest spheres (pore centers) that can be built along the channel at 1À steps; the section was obtained by cutting the protein structure along the xy-plane. See Methods.