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NRS 13, e004 | Figure 5

Puhl A, Milton F, Cvoro A, Sieglaff D, Campos J, Bernardes A, Filguiera C, Lindemann JL, Deng T, Neves F, Polikarpov I and Webb P (2015) Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal antiinflammatory drugs. Nucl Recept Sig 13, e004. doi:10.1621/nrs.13004


Figure 5. NSAIDs regulate similar genes to rosiglitazone. (A) Number of genes regulated ≥2 fold by rosiglitazone and NSAIDs. With the narrow exception of ibuprofen, more than 50% of genes were repressed by the treatments. (B) Shared and unique genes regulated by rosiglitazone and NSAIDs. 82.6% (119) of genes regulated by indomethacin, 76.7% (102) by ibuprofen and 100% (18) by diclofenac were also regulated by rosiglitazone more than 2 fold. (C) Percentage of genes with increased (red) and decreased (green) expression in response to rosiglitazone (R) or aggregated NSAIDs (N) in the specified functional categories: glucose metabolism, lipid metabolism, PPAR= PPAR signaling, anti-inflammatory pathway. .