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NRS 13, e004 | Figure 7

Puhl A, Milton F, Cvoro A, Sieglaff D, Campos J, Bernardes A, Filguiera C, Lindemann JL, Deng T, Neves F, Polikarpov I and Webb P (2015) Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal antiinflammatory drugs. Nucl Recept Sig 13, e004. doi:10.1621/nrs.13004


Figure 7. Validation of microarray analysis. Gene transcripts that displayed a response to rosiglitazone and/or NSAIDs (≥2.0 fold and adjusted p-value ≤ 0.05) were analyzed by RT-qPCR. Normalized Cp values (Critical point; CpTarget - Cp18S) were analyzed by ANOVA followed by t-tests of DMSO (vehicle) vs. treatment (Bonferroni Corrected p-value ≤ 0.05 considered significant) (GraphPad Software, version 5.01; GraphPad). * = p ≤ 0.05, ** = p ≤ 0.01. (A) Genes that show typical NSAID response patterns. C=DMSO control, R= Rosiglitazone, I= Indomethacin, Ib=Ibuprofen, D= Diclofenac. (B) Induced genes with unusual equivalent response to rosiglitazone and NSAIDs. (C) Repressed genes with equivalent response to rosiglitazone and NSAIDs.