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NRS 13, e005 | Figure 3

MacKrell JG, Yaden BC, Bullock H, Chen K, Shetler P, Bryan HU and Krishnan V (2015) Molecular Targets of Androgen Signaling that Characterize Skeletal Muscle Recovery and Regeneration. Nucl Recept Sig 13, e005. doi:10.1621/nrs.13005

 
Figure 3. In vivo androgen-mediated gene regulation in rat LA muscle. Male rats (8 weeks old) underwent gonadectomy or sham surgery. Six weeks after surgery, GDX animals were dosed daily with NARA (1 mg/kg). Cohorts (n=7-8) of GDX animals were sacrificed at hour 3, 24, 48, 72 and 7 days. A. Body weight at time of sacrifice (grams), B. Levator Ani wet weight (mg), C-G. LA muscle relative mRNA expression of IGF-1, FST, CXCR4, HGF, and GR (normalized to β-2 microglobulin; B2M) was measured via real-time PCR. Data are means ± SEM. ANOVA indicated significant differences among groups. Dunnet’s post hoc analysis set either Sham muscles or GDX (No NARA) as control and significance versus the respective group is indicated; *p<0.05 vs. Sham, † p<0.05 vs GDX.