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NRS 13, e005 | Figure 5

MacKrell JG, Yaden BC, Bullock H, Chen K, Shetler P, Bryan HU and Krishnan V (2015) Molecular Targets of Androgen Signaling that Characterize Skeletal Muscle Recovery and Regeneration. Nucl Recept Sig 13, e005. doi:10.1621/nrs.13005

 
Figure 5. NARA treatment augments satellite cell activation in gonadectomized mouse model following muscle injury. Gastrocnemius muscle from treated (NARA; 1 mg/kg/day) or untreated (Vehicle), intact or gonadectomized (GDX) mice were removed 4 days post sham or cardiotoxin (CTX) injection. A-B. Pax7 and MyoD relative mRNA expression levels. C-D. Pax7-positive cell quantifications and their representative images of immunofluorescence in gastrocnemius sections muscles 4 days after CTX injury, using an antibody specific for Pax7 (green) with the addition of DAPI (blue) staining for nuclei. Original magnification, x20. Data are expressed as means ± SEM of five mice per group. A three-way ANOVA was used to assess main effects of androgen status (Intact vs GDX), injury status (sham vs. CTX), and treatment (vehicle vs. NARA), as well as interactions between androgen status, injury status, and treatment for all variables; significance was set at P ≤0.05. *Significantly different from corresponding vehicle group. # Significantly different from corresponding sham group within androgen status model (Intact or GDX). † Significantly different between GDX and corresponding intact group.