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NRS 13, e006 | Figure 5

Thomas AL, Coarfa C, Qian J, Wilkerson JJ, Rajapakshe K, Krett NL, Gunaratne PH and Rosen ST (2015). Identification of potential glucocorticoid receptor therapeutic targets in multiple myeloma. Nucl Recept Signal 13, e006. doi:10.1621/nrs.13006

 
Figure 5. Knock-down of BCL-XL and RRM2 sensitizes cells to GC-induced apoptosis and is required for cell survival. (A and D) Confirmation of BCL-XL (A) and RRM2 (D) knock-down (KD) by siRNA at 24 and 96 h post-transfection. (B and E) Cell death measured by Annexin V staining of KD and nonspecific control (NSC) MM.1S and MM.1RL cells 96 h post-transfection. (C and F) 24 h post-transfection, KD and NSC MM.1S cells were treated with increasing concentrations of Dex for 72 h. Cell death was measured by Annexin V staining.