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NRS 14, e002 | Figure 1

Divekar SD, Tiek DM, Fernandez A and Riggins RB (2016). Estrogen-related receptor β (ERRβ) – renaissance receptor or receptor renaissance? Nucl Recept Signal 14, e002. doi:10.1621/nrs.14002

Figure 1. ERRβ splice variants. A, ERRβ mRNA. The ESRRB gene produces three distinct splice variants through inclusion or exclusion of carboxyl terminal exons. UCSC Genome Browser identifiers for each transcript are shown. B, ERRβ proteins. ERRβsf, ERRβ2, and ERRβ-Δ10 variants and corresponding amino acid (aa) differences are shown to scale along with Online Mendelian Inheritance in Man (OMIM) identifiers. C, Functional domains. Common amino acids 1-432 contain well-established DNA- and ligand-binding domains (DBD, LBD). Amino acid sequences and Phyre structural predictions [Kelley and Sternberg, 2009] of the divergent carboxyl terminal F domains of β2 and Δ10 are enlarged.